Discovering the Science Behind Zerona

From Theory To Therapy: The Science Behind ZERONA™ by Erchonia®!

From theory to therapy is a process used by Erchonia® Medical to ensure that our concepts are well supported by scientific research when developing a new application for low level laser therapy. The process begins by selecting a potential application for LLLT that could benefit the medical community and the patients they diligently serve. We quickly recognized that there was a great need for a safe and non-invasive approach for body contouring; and thus, the pursuit to develop the ZERONA™ technique was established. It was well understood that such a unique application for laser therapy was going to need the supporting molecular and clinical science.

In the attempt to analyze the effect laser therapy has on adipocytes (fat storing cells), sections of subcutaneous fat secured from abdominoplasty patients were treated with laser at 635nm. An incredible effect was observed; laser therapy demonstrated an incredible ability to create a small pore or opening in the protective membrane of the fat storing cell.

This pore enabled the stored fatty material to seep out of the cell, thus causing the once plump and rigid cell to shrink and shrivel. Our researchers quickly began comparing laser treated fat cells to non-treated cells, and the results were consistent; the non-treated adipocytes maintained their shape and size while the laser treated cluster of fat cells continued to deflate.

Figure 1. Emulsification of adipose particles subsequent to laser irradiation

Advanced scientific instruments known as scanning electron microscopy and transmission electron microscopy revealed this unique biochemical occurrence subsequent to laser irradiation. Several articles highlighting laser therapy’s ability to emulsify fat were published. A large amount of interest was generated by the potential of this interesting technology.

Our researchers understood that Erchonia® possessed a device with great potential to help those patients wishing to sculpt their bodies non-invasively. The question quickly raised, however, was how the human body would respond to laser-induced fat emulsification. In order to successfully answer this question, an initial pilot study – and later a double-blind, placebo-controlled, randomized, multi-site clinical study – was carried out.

We had great optimism that the patient would respond well to our procedure as the molecular science we performed revealed that the device did not obliterate or kill the cell. An immune response, therefore, would not be activated. The formation of a pore is the end result of natural biochemical pathways commonly used by the cell. Laser therapy simply enhances these natural processes. Moreover, low level laser therapy works on the principle of photochemistry, thus the generation of heat or vibration is not required in order to achieve this desired biological reaction.

The anticipated results for overall reduction were expected to be measured in centimeters, not inches. To our surprise, however, both the pilot and clinical study revealed the reduction of over three and a half inches across the waist, hips, and thighs after just two weeks of laser therapy.

At each treated body region, the average reduction was approximately one inch! Such a reduction does not translate into extremely visible results, but as it was expressed by the clinical trial participants, an inch reduction makes a big difference in creating a slimming feeling and allowing for smaller sized clothes to be worn. Patients receiving actual laser treatment in our clinical trial consistently made such comments as, “ I can feel a big difference,” and, “I must be getting the real thing because I am noticing a big change.”

More than 70 percent of test group participants recorded at least a satisfactory rating after the two week study was completed, while our control group recorded only a 5 percent satisfactory rating.